Endocrine Abstracts

The value of patient-reported outcomes in treatment efficacy assessment of thyroid disorders is of great importance. Recently, a new tool, Comprehensive Symptom Profile (CSP-ThSF22), has been developed to assess symptoms specific for patients with nontoxic goiters. We aimed to test practicability and sensitivity of CSP-ThSF22 in patients with euthyroid goiter undergoing thyroidectomy. A total of 78 patients with uninodular/multinodular euthyroid goiter were enrolled in this st...

The value of patient-reported outcomes in treatment efficacy assessment of thyroid disorders is of great importance. Recently, a new tool, Comprehensive Symptom Profile (CSP-ThHyperSF27), has been developed to assess symptoms specific for patients with toxic goiters. We aimed to test practicability and sensitivity of CSP-ThHyperSF27 in patients with diffuse/ multinodular toxic goiter undergoing thyroidectomy. A total of 42 patients with diffuse/multinodular toxic goiter were e...

Background: Oxytocin is a nonapeptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. Oxytocin has an effect on uterine smooth muscle contraction, blood pressure, memory, learning capability, nursing, sexual and feeding behavior. Oxytocin and vasopressin stimulate the release of insulin and glucagon from the rat pancreas. Multi organelle effects of oxytocin make it as important hormone in body.Objective: The aim of t...

Background: Macroprolactinomas account for 10% of prolactin secreting tumours. There are few studies looking at the long-term outcome of these tumours. This study analysed clinical, endocrine and radiological characteristics of macroprolactinomas and evaluated the long-term management of these patients in a tertiary care centre.Methods: Retrospective audit of 21 consecutive cases of macroprolactinomas diagnosed between 1995 and 2007 in Teesside.<p cl...

Background: Withdrawal of dopamine agonist (DA) therapy in the management of microprolactinoma is common practice. It is unclear however which patients are likely to attain long term remission.Aims: The aim of this prospective study was to identify clinical factors that might predict long term remission.Subjects: Fourty subjects (39 female, aged 24–60 years) with microprolactinoma; all had been normoprolactinaemic on DA therap...

Background: Hypopituitarism is an important sequela of traumatic brain injury (TBI) in adults. In paediatric practice, however, there are concerns that it may be under-recognised. Symptoms may be mistaken for post-concussion syndrome, which may result in delayed investigation and diagnosis. Furthermore, predictors of post-traumatic hypopituitarism (PTHP) in children have not been consistently identified. As normal pituitary function is required for growth, serial growth monito...

Background: The polycystic ovary syndrome (PCOS) is a condition defined by hyperandrogenism and ovulatory dysfunction. It is also known to be associated with insulin resistance and has many features in common with the metabolic syndrome (MS) - a cluster of risk factors that have been shown to predict a greater risk of future cardiovascular events and type 2 diabetes. While there are studies confirming that the MS is more common in PCOS, none have systematically compared the re...

The adrenolytic agent mitotane [o,p’-DDD or 1,1-(o,p’-dichlorodiphenyl)-2,2-dichloroethane] is a derivative of the insecticide DDT and is used for the treatment of adrenal carcinoma. It induces necrosis and atrophy of the adrenal cortex. Estrogenic action after single exposure but intense antiestrogenic action after repeated exposure of porcine ovarian follicles has been observed in vitro (Wojtowicz et al. 2004).The aim of the stu...

Animal and clinical models of GHRH excess suggest that GHRH provides an important trophic drive to pituitary somatotrophs. Mice in which GHRH neurons have been ablated using a novel viral ion channel transgene (GHRH-M2 mice) show marked anterior pituitary hypoplasia and GH deficiency although GH cells are present. GHRH-M2 mice are also deficient in prolactin which is surprising as GHRH has little or no direct effect on PRL synthesis or release (Le Tissier, Mol Endo 19). In mic...

NPY acts centrally to stimulate appetite and the HPA axis. During late pregnancy enhanced inhibition of parvocellular paraventricular nucleus (pPVN) corticotrophin releasing hormone (CRH)/ arginine vasopressin (AVP) neurones reduces HPA-axis stress responses1,2. We investigated activation of hypothalamic neurones regulating HPA responses to NPY, and a role for endogenous opioids in HPA hyporesponsiveness in late pregnancy.Pregnant (d21) and vi...